Heamtological and Biochemical Changes in Dengue Fever

INTRODUCTION:Vector borne viral infections endangers billions of people and World Health Organization (WHO) has estimated about 50 million cases of dengue infection every year worldwide.This disease caused by dengue ranges from a relatively minor febrile illness to a life threatening condition characterized by extensive capillary leak. AIM: The present study aimed to prevent the complications associated with dengue fever. METHODOLGY: The present study has been carried out in Gamma Diagnostic Laboratory, Moga.Through convenient sampling twenty individuals each were taken up for the study as Healthy controls (Group A) and Dengue subjects (Group B).Hb , TLC,Platelet count Prothrombin time, SGOT and SGPT estimations were done of Healthy control (Group A) and Dengue patients (Group B) RESULTS: It was found that in dengue patients the Hb values are low as compared to Healthy controls i.e Hb ranging from 5.412.7 gm/dl in dengue patients and 10.6-15.0gm/dl in Healthy controls. TLC range in Healthy controls is 5100-10800 / cumm and in dengue patients it is recorded as 1200-18500/cumm.The study also depicted that platelet count is comparatively low among dengue patients i.e 20,000-80,000 cells/cumm as compared to Healthy control groups in which platelet count ranges from 1,71,0003,12,000 cells/cumm.Prothrombin time shows significant elevation in dengue patients in comparision to healthy controls with PT range of 12-16 sec in Healthy controls and 14-42 sec in dengue patients.SGOT and SGPT values are raised in dengue patients as compared to healthy controls with SGOT ranging between 74-420 IU/L among dengue patients and 8-40IU/L among healthy control groups.The values of SGPT range from 12-30 IU/L in healthy controls and 53-390 IU/L in dengue patients. CONCLUSION: Considering the results,it was concluded that in dengue patietns Hb and platelet levels are low as compared to Healthy control group whereas TLC levels show a decrease in Dengue patients but sometimes it may also be increased due to other bacterial infections..Prothrombin time show significant elevation in dengue patients and biochemical maarkers i.e SGOT and SGPT were higher with dengue patients than those with non dengue febrile conditions.